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电话: 15623216118

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邮箱:cysh2002@whu.edu.cn

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蔡由生

性 别:男

职务/职称:课题组长/副教授

通讯地址:武汉市武昌区东湖路185号武汉大学医学部5号楼912

电子邮箱:cysh2002@163.com

电 话: 15623752985


学习简历:

2007/09-2012/06, 中科院上海药物研究所,天然药物化学(海洋天然产物),博士

2011/11-2012/05, University of Napoli Federico II, Napoli, Italy, Ph.D. student

2001/09-2005/06, 中南大学,制药工程,学士


工作经历:

2014/04-至今,武汉大学,药学院,副教授

2016/01-2018/01,夏威夷大学,博士后

2012/07-2014/03,武汉生物工程学院,医药学院,讲师

2005/07-2007/08,新和成股份有限公司、药明康德新药开发有限公司


社会兼职:

宜昌东阳光科技副总

上海辉文生物技术股份有限公司外聘专家


业绩概要:

课题组主要从事药用植物,植物内生菌,海洋微生物活性次生代谢产物研究,针对活性化合物,开展抗肿瘤、抗菌、抗炎等构效关系探究,以期获得药物先导结构。相关成果发表在J. Nat. Prod., Org. Lett., J. Org. Chem., Org. Chem. Front., Eur. J. Med. Chem., Bioorg. Chem., Nat. Prod. Rep., Chem. Rev.等杂志上。目前承担多个科研项目,包括国家自然科学基金面上项目和青年基金,国家重点研发计划项目子课题,湖北省自然科学基金面上项目,自主科研等,并与多个企业合作开展天然产物开发利用研究。


研究方向:

[1] 药用植物活性天然产物及其活性研究

[2] 植物内生真菌、海洋微生物活性化学成分研究

[3] 抗肿瘤、抗菌、抗炎活性天然产物的发现、修饰、构效关系及机理研究

承担课题与经费:

[1] 国家自然科学基金,面上项目,81973201,基于PI3K/AKT通路抑制的狗牙花属单萜吲哚生物碱的发现、抗肿瘤构效关系 与机制研究,2020/01-2023/12,直接经费55万元,在研,主持。

[2] 国家重点研发计划项目,2018YFC0311002,海洋微生物候选药物的高效发现与创制(海洋微生物天然产物的高效深度挖掘),2018/08-2021.12,26.8万,在研,子课题负责人。

[3] 国家自然科学基金,青年基金项目,21402146,两种红树林共生菌次生代谢产物及其抗肿瘤活性研究,2015/01-2017/12,25万元,已结题,主持。

[4] 中央高校基本科研-自主科研(学科交叉类),2042019kf0228,狗牙花属植物中新骨架单萜吲哚生物碱的发现、全合成、结构修饰及其抗肿瘤构效关系研究,2019/01-2020/12,20万元,在研,主持。

[5] 武汉大学医学部种子计划培育基金,狗牙花属植物中新颖骨架吲哚单萜生物碱及其PI3K/AKt通路抑制研究,2019/01-2020/12,10万元,在研,主持。

[6] 中央高校教育教学改革专项项目经费,关于开设《天然产物与大健康》通识课程的探索,2019/06-2021/06,2万元,在研,主持。

[7] 湖北省自然科学基金项目,2015CFB421,两种狗牙花属植物化学成分及其抗肿瘤,抗菌活性研究,2015/01-2016/12,3万元,已结题,主持。

[8] 湖北省重点实验室开放课题,HLPAI2014001,八角枫属植物抗肿瘤化学成分的研究,2015/01-2016/12,2万元,已结题,主持。


教学情况:

主要承担《天然药物化学》、《天然药物化学实验》、《分析化学实验》、《有机化合物波谱解析》等课程教学工作,并取得良好教学效果。


代表性论文:

[1]  Y.-S. Cai, Y.-W. Guo* and K. Krohn. Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes. Natual Product Reports, 2010, 27, 1840-1870. (SCI一区, IF: 11.876)

[2]  Y.-S. Cai, T. Kurtán, Z.-H. Miao, A. Mándi, I. Komáromi, H.-L. Liu, J. Ding, and Y.-W. Guo*. Palmarumycins BG1-BG7 and preussomerin BG1: establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra. The Journal Organic Chemistry. 2011, 76, 1821-1830.  (SCI二区TOP, IF: 4.335)

[3]  Y.-S. Cai, L.-G. Yao, A. Di Pascale, C. Irace, E. Mollo, O. Taglialatela-Scafati, Y.-W. Guo*. Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi. Tetrahedron 2013, 69, 2214-2219.  (SCI三区, IF: 2.233)

[4]  L.-F. Liang#, T. Wang#, Y.-S. Cai#, W.-F. He, P. Sun, Y.-F. Li, Q. Huang, O. Taglialatela-Scafati*, H.-Y. Wang*, Y.-W. Guo*. Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors. European Journal of Medicinal Chemistry. 2014, 79, 290-297. (SCI一区, IF: 5.572)

[5]  Z.-F. Zhou, M. Menna, Y.-S. Cai, and Y.-W. Guo*. Polyacetylenes of marine origin: chemistry and bioactivity. Chemical Reviews, 2015, 115 (3), 1543–1596.  (SCI一区, IF: 52.758)

[6]  Y.-S. Cai, A. M. Sarotti, D. Gündisch, T. P. Kondratyuk, J. M. Pezzuto, J. Turkson, S. Cao*. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4630-4634. (SCI三区, IF: 2.572)

[7]  S.-Y. Zhou, T.-L. Zhou, G. Qiu, X. Huan, Z.-H. Miao, S.-P. Yang, S. Cao, F. Fan, Y.-S. Cai*. Three new cytotoxic monoterpenoid bisindole alkaloids from Tabernaemontana bufalina. Planta Medica, 2018, 84, 1127-1133. (SCI三区, IF: 2.687)

[8]  S.-Y. Zhou, F. Fan, J.-Z. Sun, Z. Guo, W.-T. Sun, L. Chen, Q.-Q. Tang, G. Qiu, S.-P. Yang, J. Yu, Y.-S. Cai*. Cytotoxic alkaloids from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin. Phytochemistry Letters 2018, 26, 195-198. (SCI四区, IF: 1.459)

[9]  Y.-S. Cai, J.-Z. Sun, Q.-Q. Tang, F. Fan & Y.-W. Guo*. Acanthiline A, a pyrido[1,2-a]indole alkaloid from Chinese mangrove Acanthus ilicifolius. Journal of Asian Natural Products Research, 2018, 20(11), 1088-1092. (SCI四区, IF: 1.345)

[10] Y.-S. Cai*, A. M. Sarotti, T.-L. Zhou, R. Huang, G. Qiu, C. Tian, Z.-H. Miao, A. Mándi, T. Kurtán, S. Cao,* S.-P. Yang*. Flabellipparicine, a flabelliformide-apparicine-type bisindole alkaloid from Tabernaemontana divaricata. Journal of  Natural Products, 2018. 81, 1976-1983. (SCI二区TOP, IF:3.779)

[11] Y.-S. Cai,* C. Wang, C. Tian, W.-T. Sun, L. Chen, D. Xiao, S.-Y. Zhou, G. Qiu, J. Yu, K. Zhu, and S.-P. Yang* Octahydro-protoberberine and protoemetine-type alkaloids from the stems of Alangium salviifolium and their cytotoxicity. Journal of  Natural Products, 2019, 82, 2645-2652. (SCI二区TOP, IF:3.779)

[12] Y.-S. Cai,# Z. Wu,# J.-R. Wang, X.-Q. Zheng, J. Xu, G. Qiu, J. Yu*. Spiroalanfurantones A-D, four eudesmanolide-furan sesquiterpene adducts with a pentacyclic 6/6/5/5/5 skeleton from Inula helenium. Organic Letters, 2019, 21, 9478-9482. (SCI一区, IF: 6.091)

[13] Y.-S. Cai,# Z. Wu,# X.-Q. Zheng, C. Wang, J.-R. Wang,c X.-X. Zhang, G. Qiu, K. Zhu, S. Cao and J. Yu*. Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide–pyrrolizidine skeleton from Inula helenium. Organic Chemistry Fronters, 2020, 7, 303-309. (SCI一区, IF: 5.155)

[14] Z. Wu,# Y.-S. Cai,# R. Yuan, Q. Wan, D. Xiao, J. Lei, J. Yu* Bioactive pterocarpans from Trigonella foenum-graecum L. Food Chemistry. 2020, 313, 126092/1-7. (SCI一区, IF: 6.306)

[15] C.-K. Tian, R.-Y. Yuan,* Y.-X. Wang, L. Chen, Z. Wu, L. Liu, Y.-S. Cai*  Two new guaiane sesquiterpenes from the fruiting bodies of Lactarius Deliciosus. J. Asian Nat. Prod. Res. 2020, DOI: 10.1080/10286020.2019.1695781. (SCI四区, IF: 1.345)

[16] Y.-S. Cai, J. Xu, M. Chen, D. Wang, Y. Yang, A. Manavalan, X. Wu, Y. Liu,* S. Cao* Compound analysis of Jing Liqueur and nrf2 activation by Jing liqueur-one of the most popular beverages in China. Beverages 2020, 6 (1), 1-18. (SCIE)

[17] Y.-S. Cai, W.-X. Cui, W. Tang, Y.-W. Guo*; Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa. Bioorganic Chemistry 2020, 104, 104167/1-8. (SCI二区TOP, IF: 4.831)