沈坤
性别：男
职务/职称：副教授，博士生导师
通讯地址：武汉大学药学院，武汉市武昌区东湖路185号，邮编430071
办公地址：武汉大学医学部5号楼902室
学习简历：
2008.9 – 2013.7 中国科学院上海有机化学研究所，理学博士
2004.9 – 2008.6 武汉大学化学与分子科学学院，理学学士
工作简历：
2024 – 至今 武汉大学药学院，副教授
2018 – 2024 武汉大学药学院，特聘副研究员
2013.8 – 2018.7 美国杜克大学化学系，博士后
研究兴趣与方向:
有机合成方法学，药物合成化学，抗肿瘤药物开发
承担课题:
1. 国家自然科学基金面上项目（22271225），2023–2026，主持。
2. 国家自然科学基金青年项目（21901192），2020–2022，主持。
3. 国家重点研发计划项目（2021YFA0910503），2021–2026，子课题主持。
4. 湖北省自然科学基金面上项目（2022CFB221），2022–2024，主持。
5. 湖北省自然科学基金面上项目（2019CFB129），2019–2021，主持。
教学情况:
本科生：有机化学
研究生：高等有机化学
代表性论文:
1. Liu, W.;# Xing, Y.;# Yan, D.;# Kong, W.;* Shen, K.* Nickel-Catalyzed Electrophiles-Controlled Enantioselective Reductive Arylative Cyclization and Enantiospecific Reductive Alkylative Cyclization of 1,6-Enynes. Nat. Commun. 2024, 15, 1787.
2. Wen, S.;# Bu, J.;# Shen, K.* Dual Nickel- and Photoredox-Catalyzed Asymmetric Reductive Cross-Coupling To Access Chiral Secondary Benzylic Alcohols. J. Org. Chem. 2024, 89, 16134−16144.
3. Yan, D.;# Wen, S.;# Xing, Y.; Bu, J.; Shen, K.* Nickel-Catalyzed Reductive anti-Arylative Cyclization of Alkynyl Enones with Aryl Halides. J. Org. Chem. 2024, 89, 2223–2231.
4. Xing, Y.;# Tian, Z.;# Shen, K.* Nickel-Catalyzed Regio- and Stereoselective Reductive Alkylative Cyclization of 1,6-Enynes with Alkyl Bromides. Adv. Syn. Catal. 2024, 366, 3802–3807.
5. Xing, Y.; Yan, D.; Wen, S.; Bu, J.; Shen, K.* Nickel-Catalyzed Reductive anti-Arylative Cyclization of 1,6-Enynes with Aryl Halides. Chin. J. Org. Chem. 2024, 44, 1938–1948.
6. Huang, Y.; Ye, Z.; Wan, X.; Yao, G.; Duan, J.; Liu, J.; Yao, M.; Sun, X.; Deng, Z.; Shen, K.;* Jiang, H.;* Liu, T.* Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules. Adv. Sci. 2023, 10, 2300889.
7. Shen, K.; Yu, H.; Xie, B.; Meng, Q.;* Dong, C.;* Shen, K.;* Zhou, H.* Anticancer or Carcinogenic? The Role of Estrogen Receptor β in Breast Cancer Progression. Pharmacology & Therapeutics 2023, 242, 108350.
8. Cheng, X.;# Zhang, C.;# Shen, K.;# Liu, H.; Bai, C.; Ding, Q.; Guan, M.; Wu, J.; Tian, Z.; Chen, D.; Cai, L.;* Hong, X.;* Xiao, Y.* Novel Diketopyrrolopyrrole NIR-II Fluorophores and DDR Inhibitors for in vivo Chemo-photodynamic Therapy of Osteosarcoma. Chem. Eng. J. 2022, 424, 136929.
9. Ye, Z.; Shi, B.; Huang Y.; Ma, T.; Xiang, Z.; Hu, B.; Kuang, Z.; Huang, M.; Lin, X.; Tian, Z.; Deng, Z.; Shen, K.; Liu, T.* Revolution of Vitamin E Production by Starting from Microbial Fermented Farnesene to Isophytol. The Innovation 2022, 3, 100228.
10. Ye, Z.; Huang, Y.; Shi, B.; Xiang, Z.; Tian, Z.; Huang, M.; Wu, L.; Deng, Z.; Shen, K.; Liu, T.* Coupling Cell Growth and Biochemical Pathway Induction in Saccharomyces Cerevisiae for Production of (+)-Valencene and Its Chemical Conversion to (+)-Nootkatone. Metab. Eng. 2022, 72, 107–115.
11. Wang, L.; Wang, H.; Shen, K.; Park, H.; Zhang, T.; Yuan, H.; Wu, Z.;* Wang, Q.;* Li, Z. Development of Novel 18F-PET Agents for Tumor Hypoxia Imaging. J. Med. Chem. 2021, 64, 5593–5602.
12. Luo, M.;# Xu, H.;# Dong, Y.; Shen, K.; Lu, J.; Yin, Z.; Qi, M.; Sun, G.; Tang, L.; Xiang, J.; Deng, Z.; Diskschat, J. S.;* Sun, Y.* The Mechanism of Dehydrating Bimodules in trans-Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin. Angew. Chem. Int. Ed. 2021, 60, 19139–19143.
13. Kong, L.;# Xu, G.;# Liu, X.;# Wang, J.; Tang, Z.; Cai, Y.; Shen, K.; Tao, W.; Zheng, Y.; Deng, Z.; Price, N. P. J.; Chen, W.* Divergent Biosynthesis of C-Nucleoside Minimycin and Indigoidine in Bacteria. iScience 2019, 22, 430–440.
14. Shen, K.; Wang, Q.* Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles. J. Am. Chem. Soc. 2017, 139, 13110–13116.
15. Shen, K.; Wang, Q.* Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents. Chem. Sci. 2017, 8, 8265–8270.
16. Shen, K.;# Logan, A. W. J.;# Colell, J. F. P.;# Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.;* Malcolmson, S. J.;* Wang, Q.* Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization. Angew. Chem. Int. Ed. 2017, 56, 12112–12116.
17. Colell, J. F. P.; Emondts, M.; Logan, A. W. J.; Shen, K.; Bae, J.; Shchepin, R. V.; Ortiz, G. X.; Spannring, P.; Wang, Q.; Malcolmson, S. J.; Chekmenev, E. Y.; Feiters, M.; Rutjes, F. P. J. T.; Blümich, B.;* Theis, T.;* Warren, W. S.* Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange. J. Am. Chem. Soc. 2017, 139, 7761–7767.
18. Shen, K.; Han, X.;* Lu, X.* Hu, Z. Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids. Tetrahedron Lett. 2017, 58, 3768–3771.
19. Shen, K.; Wang, Q.* Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams. Org. Chem. Front. 2016, 3, 222–226.
20. Hemric, B. N.; Shen, K.; Wang, Q.* Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines. J. Am. Chem. Soc. 2016, 138, 5813–5816.
21. Shen, K.; Wang, Q.* Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines. Chem. Sci. 2015, 6, 4279–4283.
22. Shen, K.; Han, X.;* Xia, G.; Lu, X.* Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives. Org. Chem. Front. 2015, 2, 145–149.
23. Shen, K.; Han, X.;* Lu, X.* Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source. Org. Lett. 2013, 15, 1732–1735.
24. Shen, K.; Han, X.;* Lu, X.* Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids. Org. Lett. 2012, 14, 1756–1759.
