熊磊

性别：男

职务/职称: 特聘副研究员

通讯地址（含邮编）：武汉大学医学部8号楼8楼808，430075 

学习简历：

2012/9-2017/3，上海交通大学，生物学，博士

2009/9-2012/6，中南民族大学，生物化学与分子生物学，硕士

2005/9- 2009/6，武汉工程大学，生物技术，学士

工作简历：

2019/8-至今，武汉大学药学院，特聘副研究员

2017/6-2019/7，武汉大学药学院，博士后

研究领域:

DNA骨架磷硫酰化修饰

研究兴趣与方向:

古菌DNA磷硫酰化修饰系统及其抗病毒机制研究；古菌组蛋白与DNA磷硫酰化系统的相互作用及其生理功能的研究

科研成果（至少应有近五年的代表性成果）:

1. Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral system in archaea. Nature Communications，2019, 10(1): 1688.

2. Lei Xiong, Huahua Jian, Xiang Xiao*. Deep-sea bacterium Shewanella piezotolerans WP3 has two dimethyl sulfoxide reductases in distinct subcellular locations. Applied and Environmental Microbiology, 2017.9, 83(18).

3. Lei Xiong, Huahua Jian, Yuxia Zhang, Xiang Xiao*. The two sets of DMSO respiratory systems of Shewanella piezotolerans WP3 are involved in deep sea environmental adaptation. Frontiers in microbiology, 2016.9.07, 7: 1418.

4. Huahua Jian, Lei Xiong, Guanpeng Xu, Xiang Xiao, Fengping Wang*. Long 5' untranslated regions regulate the RNA stability of the deep-sea filamentous phage SW1. Scientific Reports, 2016.2.22, 6(1): 21908.

5. Huahua Jian, Lei Xiong, Guanpeng Xu, Xiang Xiao*. Filamentous phage SW1 is active and influences the transcriptome of the host at high-pressure and low-temperature. Environmental microbiology reports, 2016.6, 8(3): 358~362

6. Yan Yang#, Guanpeng Xu#, Jingdan Liang#, Ying He, Lei Xiong, Hui Li, Douglas Bartlett, Zixin Deng, Zhijun Wang*, Xiang Xiao*. DNA backbone sulfur-modification expands microbial growth range under multiple stresses by its anti-oxidation function. Scientific Reports, 2017.6.14, 7(1): 3516.