刘峥

职务/职称：特聘副研究员

通讯地址：湖北省武汉市武昌区东湖路185号，武汉大学药学院，430071

邮箱：ZhengL23@whu.edu.cn

学习经历：

2006.09--2010.07安徽农业大学 生命科学学院，理学学士

2010.09--2015.06中国科学技术大学 生命科学学院，理学博士

工作经历：

2017.04--2021.11加州大学欧文分校 医学院，博士后

2023.04 - 至今 武汉大学 药学院, 特聘副研究员

科研方向：

病原微生物与宿主互作及靶向药物研究

科研成果：

1. Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M#. & Jin, R#. (2023) Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Nature Communications. 14, 2338.

2. Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Science Advances. 43, eabi4582.

3. Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M#. & Li, X#. (2014) Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Research. 42, 9470-83.

4. Chen, P*., Tao, L*., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M#. & Jin, R#. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Science. 360, 664-669.

5. Chen, P*., Zeng, J*., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M#. & Jin, R#. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Nature Communications. 12, 3748.

6. Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R. (2019) Structure of the full-length Clostridium difficile toxin B, Nature Structural & Molecular Biology. 26, 712-719.

7. Chen, B., Liu, Z., Perry, K., & Jin, R. (2022) Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Scientific Reports. 12, 9028.

8. Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, FEBS Journal. 286, 874-881.

9. Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K. (2022) Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Cell Reports. 39, 110760.

10. Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X. (2015) Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, PLoS One. 10, e0120304.