沈坤

性别：男

职务/职称：副研究员

通讯地址：武汉大学药学院，武汉市武昌区东湖路185号，邮编430071

学习简历：

2008.9 – 2013.7  中国科学院上海有机化学研究所，理学博士

2004.9 – 2008.6  武汉大学化学与分子科学学院，理学学士

工作简历：

2018.9至今     武汉大学药学院，副研究员

2013.8 – 2018.7  美国杜克大学化学系，博士后

研究领域:

有机化学，药物化学，化学生物学

研究兴趣与方向:

1. 合成方法学，手性药物与天然产物的不对称合成

2. 创新药物的研究与开发

3. 药物分子作用机制研究

科研成果（至少应有近五年的代表性成果）:

1.Shen, K.; Wang, Q.* “Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles.” J. Am. Chem. Soc. 2017, 139, 13110–13116.

2.Shen, K.;# Logan, A. W. J.;# Colell, J. F. P.;# Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.;* Malcolmson, S. J.;* Wang, Q.* “Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.” Angew. Chem. Int. Ed. 2017, 56, 12112–12116. (Selected as Very Important Paper and Highlighted on Front Cover.)

3.Shen, K.; Wang, Q.* “Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents.” Chem. Sci. 2017, 8, 8265–8270.

4.Hemric, B. N.; Shen, K.; Wang, Q.* “Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines.” J. Am. Chem. Soc. 2016, 138, 5813–5816.(Highlighted in Synfacts.)

5.Shen, K.; Wang, Q.* “Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams.” Org. Chem. Front. 2016, 3, 222–226.

6.Shen, K.; Wang, Q.* “Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines.”Chem. Sci. 2015, 6, 4279–4283.

7.Shen, K.; Han, X.;* Lu, X.* Hu, Z. “Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids.” Tetrahedron Lett. 2017, 58, 3768–3771.

8.Shen, K.; Han, X.;* Xia, G.; Lu, X.* “Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives.” Org. Chem. Front. 2015, 2, 145–149. (HOT articles in Organic Chemistry Frontiers in 2015 and Celebrateing the 80th Birthday of Professor Ei-ichi Negishi.)

9.Shen, K.; Han, X.;* Lu, X.* “Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source.” Org. Lett. 2013, 15, 1732–1735.

10.Shen, K.; Han, X.;* Lu, X.* “Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids.” Org. Lett. 2012, 14, 1756–1759.