童静（Tong Jing) 

性别：女

职务/职称：副教授

通讯地址（含邮编）：武汉大学医学部5号楼药学院 430071

学习简历：

2007~2014年于武汉大学药学院生物化学及分子生物学专业攻读博士学位，研究方向分子药理学。

2002~2004年于武汉大学药学院生物化学及分子生物学专业攻读硕士学位，研究方向药理学。

工作简历：

2004~2016年，武汉大学药学院，讲师；

2009~2021年，美国夏威夷大学，访问学者；

2016年~至今，武汉大学药学院，副教授。

2017年~至今，美国明尼苏达大学，博士后

研究领域：

中药活性。

研究兴趣与方向：

传统药物对内质网应激与非折叠蛋白反应的调控及治疗神经退行性疾病的作用；

传统药物对糖脂代谢的调控及对糖尿病、非酒精性肝损伤的治疗作用。

教学情况：

先后承担过《药理学》、《实验药理学》、《生物药剂学与药代动力学》、《药用植物学》、《中药学》的教学工作。

主要科研成果：

1.Jing Tong, Qigui Mo, Bingxin, Ma, Lanlan Ge, Gao Zhou, Youwei Wang*. The protective effects ofCichorium glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro. Food & Function 2016, 8,209-220. DOI:10.1039/c6fo01531j

2. Tong, J.; Wang, Y.; Lu, Y.*, In vitro evaluation of inorganic and methyl mercury mediated cytotoxic effect on neural cells derived from different animal species. Journal of Environmental Sciences 2016, 41, 138-45. doi.org/10.1016/j.jes.2015.04.036

3. Tong, J.; Ma, B.; Ge, L.; Mo, Q.; Zhou, G.; He, J.; Wang, Y.*, Dicaffeoylquinic Acid-Enriched Fraction of Cichorium glandulosum Seeds Attenuates Experimental Type 1 Diabetes via Multipathway Protection.Journal of agricultural and food chemistry 2015, 63, 10791-802. DOI:10.1021/acs.jafc.5b04552

4.Tong, J.; Yao, X.; Zhou, G.; Chen, Y.; Ma, B.; Wang, Y.*, Hepatoprotective activity of flavonoids from seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology 2015,174, 355-63. doi.org/10.1016/j.jep.2015.08.045

5.Tong, J.; Buch, S.; Yao, H.; Wu, C.; Tong, H.; Wang, Y.*; Lu, Y.*, Monocytes-Derived Macrophages Mediated Stable Expression of Human Brain-Derived Neurotrophic Factor, a Novel Therapeutic Strategy for NeuroAIDS. PLoS ONE 2014, 9, e82030.

6.Jing Tong, Hank Trapido-rosenthal, Jun Wang, Youwei Wang, Qing X Li*, Yuanan Lu*. Antiviral activities and putative identification of compounds in microbial extracts from the Hawaiian coastal waters.Marine Drugs 10：521-538, 2012.

7.Jing Tong, You-wei Wang, Yuan-an Lu*. New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 13：56-82, 2012

8.Ma, B.; Tong, J.; Zhou, G.; Mo, Q.; He, J.; Wang, Y.*, Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice. Journal of Functional Foods 2016, 21, 455-62.

9.Chen, Y.; Tong, J.; Ge, L.; Ma, B.; He, J.; Wang, Y.*, Ethyl acetate fraction of Terminalia bellirica fruit inhibits rat hepatic stellate cell proliferation and induces apoptosis. Industrial Crops and Products 2015, 76, 364-73.

10.Wang, H.; Tong, J.; Bi, Y.; Wang, C.; Guo, L.; Lu, Y.*, Evaluation of mercury mediated in vitro cytotoxicity among cell lines established from green sea turtles. Toxicology in vitro 2013, 27, 1025-30.

11.Ma, B.; Wang, J.; Tong, J.; Zhou, G.; Chen, Y.; He, J.; Wang, Y.*, Protective effects of Chaenomeles thibetica extract against carbon tetrachloride-induced damage via the MAPK/Nrf2 pathway. Food & function 2016, 7, 1492-500.

12.Huang, B.; Chen, Y.; Ma, B.; Zhou, G.; Tong, J.; He, J.; Wang,Y.*, Protective effect of Cichorium glandulosum seeds from ultraviolet B-induced damage in rat liver mitochondria. Food & Function 2014, 5: 869-75.

13.Tian, J.; Chen, Y.; Ma, B.; He, J.; Tong, J.; Wang, Y.*, Drosera peltata Smith var. lunata (Buch.-Ham.) C. B. Clarke as a feasible source of plumbagin: phytochemical analysis and antifungal activity assay. World Journal of Microbiology and Biotechnology 2014, 30, 737-45.

14.Ding, H.; Tong, J.*; Wu, S.; Yin, D.; Yuan, X.; Wu, J.; Chen, J.; Shi, G., Modulation of Kupffer cells on hepatic drug metabolism. World Journal of Gastroenterology 2004, 10, 1325-28.

15.Ding, H.; Huang, J.; Tong, J.; Yuan, X.; Yu, J.*, Influence of Kupffer cells on hepatic signal transduction as demonstrated by second messengers and nuclear transcription factors. World Journal of Gastroenterology2003, 9, 2523-27.

主持课题情况:

1.2012年~2014年，药用植物学理论与实践一体化教学模式改革（武汉大学）。

2.2014年~2015年，药学硕士专业学位中基于职业案例分析的能力考核模式研究（全国药学专业学位研究生教育指导委员会）。

3.2016年~2018年，国家青年自然科学基金项目: 81503356，菊苣子作用于糖尿病多靶点活性成分及其整合作用机制研究。