杨志刚
性别：男
职务/职称：副教授
通讯地址：武汉大学药学院（湖北省武汉市东湖路185号）
办公地址：东湖路185号武汉大学医学部1号楼6楼
邮编：430071
学习简历：
2002年9月至2006年7月 四川大学化学学院获学士学位
2006年9月至2011年6月 四川大学化学学院获博士学位
工作经历：
2011年7月至2013年6月 新加坡南洋理工大学博士后
2013年6月至今 武汉大学药学院副教授
研究领域：
药物化学、药物材料
研究兴趣与方向：
1. 肿瘤诊疗药物的设计，开发智能的19F MRI可视化药物载体，并将其应用于肿瘤等重大疾病的诊断、治疗以及药物传递系统的监测
2. 含氟药物、含氟功能材料的高效合成及生物活性研究
科研项目：
1. 中南医院转化医学及交叉学科研究联合基金项目，2023–2026
2. 湖北省自然科学基金一般面上项目，2022–2024
3. 肺癌的高灵敏谱学与成像新技术研究，科技部国家重点研发计划项目，2019–2024
4. 慢阻肺药物个性化干预与治疗的新技术和新方法，科技部国家重点研发计划项目，2016–2021
5. 中国科学院有机氟化学重点实验室开放课题，2014–2016, 2018–2020
6. 湖北省高校省级教学改革研究项目，2017–2019
7. 国家自然科学基金青年科学基金项目，2015–2017
获奖情况：
1. 药学院2018年青年教师教学竞赛，二等奖
2. 药学院2020年青年教师教学竞赛，三等奖
3. 武汉大学2020年网络实验室安全知识竞赛，实验室安全知识达人
4. 武汉大学第一届实验室安全技能竞赛（2024年），二等奖
学术兼职：
湖北省药学会第十三届理事会药事管理专业委员会委员
代表性论文：
(1) Qianying Zhou, Mi Huang, Yongcun Shen, Zhenling Chen,* Liying Xu, and Zhigang Yang*, “Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4+1] Annulation of Difluorocarbene and Antitumor Activity Evaluation” Org. Lett. 2024, 26, 1212−1217.
(2) Yuyin Mao, Na Li, Jie Liu,* Zhong-Xing Jiang, and Zhigang Yang*, “TBAF-Mediated [3+1] Cycloaddition of Difluorocarbene to Access gem-Difluorinated 1,2-Diazetidine Analogues as Potent Anticancer Agents” Org. Lett. 2023, 25, 7567−7572.
(3) Xiangyu Li, Na Li, Lan Yang, Rui Jiang, Yong He, Jian Shi, Zhong-Xing Jiang, and Zhigang Yang*, “Switchable Nucleophilic Site Enables Expedient Synthesis of CF3‑Containing Thiazoles and Allenes from 1,3-Enynes” ACS Catal. 2023, 13, 12755−12765.
(4) Yushan Xiao, Yimin Jia, Jinfeng Huang, Xiangyu Li, Zhiwen Zhou, Jing Zhang, Mou Jiang, Xin Zhou, Zhong-Xing Jiang*, and Zhigang Yang*, “Synthesis of SCF3-Substituted Sulfonium Ylides from Sulfonium Salts or α-Bromoacetic Esters” Adv. Synth. Catal. 2022, 364, 738−743.
(5) Yimin Jia, Yuan Yuan, Jinfeng Huang, Zhong-Xing Jiang*, and Zhigang Yang*, “Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene” Org. Lett. 2021, 23, 2670−2675.
(6) Jinfeng Huang, Yimin Jia, Xiangyu Li, Jianli Duan, Zhong-Xing Jiang, and Zhigang Yang*, “Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes” Org. Lett. 2021, 23, 2314−2319.
(7) Na Wang, Yimin Jia, Hongmei Qin, Zhong-xing Jiang, and Zhigang Yang*, “Chlorotrifluoromethylthiolation of Sulfur Ylides for the Formation of Tetrasubstituted Trifluoromethylthiolated Alkenes” Org. Lett. 2020, 22, 7378−7382.
(8) Ying Zheng, Yimin Jia, Yuan Yuan, Zhong-Xing Jiang,* and Zhigang Yang*, “F- −Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph3P+CF2CO2-: Synthesis of α-CF3‑Substituted Esters” J. Org. Chem. 2020, 85, 10913−10923.
(9) Hongmei Qin, Yimin Jia, Na Wang, Zhong-Xing Jiang and Zhigang Yang*, “Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides” Chem. Commun. 2020, 56, 8265−8268.
(10) Jing Zhang, Yuan Yuan, Yu Li, Hao Yang, Huaibin Zhang, Shizhen Chen, Xin Zhou, Zhigang Yang*, and Zhong-Xing Jiang*, “Synthesis of Branched Monodisperse Oligoethylene Glycols and 19F MRI-Traceable Biomaterials through Reductive Dimerization of Azides” J. Org. Chem. 2020, 85, 6778−6787.
(11) Yimin Jia, Long Chen, Huaibin Zhang, Ying Zheng, Zhong-Xing Jiang and Zhigang Yang*, “Electrophilic chloro(ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: facile synthesis of β-chloroethers” Org. Biomol. Chem. 2018, 16, 7203−7213.
(12) Yimin Jia, Hongmei Qin, Na Wang, Zhong-Xing Jiang, and Zhigang Yang*, “Fe2O3‑promoted intermolecular chlorotrifluoromethylthiolation of alkenes” J. Org. Chem. 2018, 83, 2808−2817.
(13) Haotian Xing, Long Chen, Yimin Jia, Zhongxing Jiang*, Zhigang Yang*, “Fe2O3-catalyzed Pummerer Rearrangement of Acyl Chlorides and Sulfoxides: Facile Synthesis of Alkylthiomethyl Ester” Tetrahedron Lett. 2017, 58, 2199−2202.
(14) Zihong Wan, Yu Li, Shaowei Bo, Ming Gao, Xuemeng Wang, Kai Zeng, Xin Tao, Xuefei Li, Zhigang Yang*, and Zhong-Xing Jiang*, “Amide bond-containing monodisperse polyethylene glycols beyond 10 000 Da” Org. Biomol. Chem. 2016, 14, 7912−7919.
(15) Long Chen, Haotian Xing, Huaibin Zhang, Zhong-Xing Jiang* and Zhigang Yang*, “Copper-catalyzed intermolecular chloroazidation of α,β-unsaturated amides” Org. Biomol. Chem. 2016, 14, 7463−7467.
(16) Mingyang Fu, Long Chen, Yongpeng Jiang, Zhong-Xing Jiang,* and Zhigang Yang*, “Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes” Org. Lett. 2016, 18, 348−351.
(17) Guiquan Xia, Yu Li, Zhigang Yang*, and Zhong-Xing Jiang*, “Development of a Scalable Process for α-Amino-ω-methoxyl-dodecaethylene Glycol” Org. Process Res. Dev. 2015, 19, 1769−1773.
(18) Yu Li, Qi Guo, Xuefei Li, Hua Zhang, Fanghua Yu, Weijiang Yu, Guiquan Xia, Mingyang Fu, Zhigang Yang*, Zhong-Xing Jiang*, “Fluorous synthesis of mono-dispersed poly(ethylene glycols)” Tetrahedron Lett. 2014, 55, 2110−2113.
(19) Zhigang Yang and Jianrong (Steve) Zhou*, “Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands” J. Am. Chem. Soc. 2012, 134, 11833−11835.
(20) Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives” Org. Lett. 2011, 13, 596−599.
(21) Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex” Chem. Eur. J. 2010, 16, 6632−6637.
(22) Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su, Changwei Hu*, “Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins” Adv. Synth. Catal. 2008, 350, 2001−2006.
授权发明专利：
(1) 杨志刚，江中兴，邢皓添，“一种制备烷基硫甲基酯类化合物的方法”，专利号：ZL201710221529.X，授权日期：2018.08.21。
(2) 杨志刚，江中兴，付名扬，“一种烯烃的卤代三氟甲基化反应方法”，专利号：ZL201610007932.8，授权日期：2018.03.13。
