张帆
性别：女
职务/职称：教授/博士生导师
通讯地址：湖北省武汉市武昌区东湖路185号武汉大学药学院
办公地址：武汉大学医学部1号楼
学习背景
2007.9-2012.6 中国科学院微生物研究所，博士
2003.9-2007.6 吉林大学药学院，学士
工作经历
2021.7至今 武汉大学大学药学院，教授，博士生导师
2015.5-2021.5 美国威斯康星大学麦迪逊分校药学院，助理科学家
2014.5-2015.5 美国威斯康星大学麦迪逊分校药学院，博士后
2013.4-2014.4 加拿大曼尼托巴大学化学学院，博士后
2012.7-2013.3 中国科学院微生物研究所，助理研究员
研究领域
微生物来源抗耐药菌先导化合物的开发
研究方向
1. 利用组学技术开展海洋微生物活性天然代谢产物的研究，从中发现新型抗生素的先导化合物
2. 复杂天然产物结构鉴定新方法的建立
3. 研究高活性天然产物的生物合成途径
4. 高活性天然产物结构改造和构效关系的研究
招生招聘
1.欢迎勤奋、有理想的硕士博士研究生（具有药学、化学、生物专业背景皆可）加入本课题组。
2.诚聘博士后1-2名，具有天然产物化学、生物信息学或天然产物生物合成背景均可，具体薪酬根据相关学校政策以及个人教育经历和研究背景有所浮动，年收入约为20-30万元（税前），课题组支持和推荐申请博士后科学基金及重点博士后支持项目。
3.诚聘微生物、药学或化学专业背景科研助理1-2名，待遇从优。
4.长期欢迎本科生加入实验室实习，进行大创或毕设的研究。
成果概要
近五年来，在海洋微生物来源新型药物开发领域的取得了一系列重要进展，目前，已发表SCI论文20篇，其中作为第一作者或共同第一作者发表研究论文13篇，包括Science 1篇、Journal of Clinical Investigation 1篇、Organic Letters 3篇，并在海洋天然产物药用价值开发方面申请两项专利：一项国际专利，一项美国专利 （已授权）。研究工作相关研究成果被国内外80余家媒体报道，并被Science和Nature Reviews Drug Discovery等杂志重点刊文评论。担任Marine Drugs.等8种国际学术刊物审稿人工作。
国际会议特邀报告
1. "Turbinmicin, a New Antifungal with Potent In Vivo Efficacy Against Pan Resistant Candida auris and Aspergillus fumigatus. Gordon Research Conference on Marine Natural Products, Ventura, CA, February 23-28, 2020.
授权专利
1. Bugni, T.; Zhang, F.; Braun, D.; Ananiev, G.; Hoffmann, F. M. Biemamides and related scaffolds as inhibitors of transforming growth factor-beta signaling. US Patent App. 16/551, 534.
2. Bugni, T.; Zhang, F.; Braun, D.; Andes, D. R.; Miao, Z. Turbinmicin compounds, compositions and uses thereof. International application PCT/US2019/068786.
发表文章
1. Zhang, F.;# Zhao, M.;# Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.*; Bugni, T. S.* A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science 2020, 370, 974–978.
2. Zhao, M.;# Zhang, F.;# Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.*; Andes, D. R.* Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking. J. Clin. Investig. 2021, 131, e145123.
3. Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S.* MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product. Org. Lett. 2020, 22, 1275–1279.
4. Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S.* Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derived Micromonospora sp. bacterium using MS-based metabolomics approaches. J. Nat. Prod. 2019, 82, 3432–3439.
5. Zhang, F.; Braun, D. R.; Rajski, S. R.; DeMaria, D.; Bugni, T. S.* Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium Enhygromyxa sp. Mar. Drugs. 2019, 17, 698.
6. Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.* Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition. Org. Lett. 2018, 20, 5529–5532.
7. Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S.* Thalassosamide, a siderophore discovered from the marine-derived bacterium Thalassospira profundimaris. J. Nat. Prod. 2017, 80, 2551–2555.
8. Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S.* Application of 3D NMR for structure determination of peptide natural products. J. Org. Chem. 2015, 80, 8713–8719.
9. Ren, J.;# Zhang, F.;# Liu, X.; Li, L.; Liu, G.; Liu, X.; Che, Y.* Neoectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp. Org. Lett. 2012, 24, 6226–6229.
10. Zhang, F.; Li, L.; Niu, S.; Si, Y.; Guo, L.; Jiang, X.; Che, Y.* A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia africana. J. Nat. Prod. 2012, 75, 230–237.
11. Zhang, F.;# Ding, G.;# Li, L.; Cai, X.; Si, Y.; Guo, L.; Che, Y.* Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G. Org. Biomol. Chem. 2012, 10, 5307–5314.
12. Ding, G.;# Zhang, F.;# Chen, H.; Guo, L.; Zou, Z.; Che, Y.* Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp. J. Nat. Prod. 2011, 74, 286–291.
13. Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.* Allenyl and allkynyl phenyl ethers from the endolichenic fungus Neurospora terricola. J. Nat. Prod. 2009, 72, 1782–1785.
14. Schorn, M. A.; Stefan, V.; [et al, including Zhang, F.] A community resource for paired genomic and metabolomic data mining. Nat Chem Biol. 2021, 17, 363–368.
15. Vinnik, V.; Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M.* Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58. ACS Chem. Biol. 2021, 16, 125–135.
16. Chanana, S.; Thomas, C. S.; Zhang, F.; Rajski, S. R.; Bugni T. S.* hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R. Metabolites 2020, 10, 297.
17. Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.; Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R.* The antimicrobial potential of Streptomyces from insect microbiomes. Nat. Commun. 2019, 10, 516.
18. Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.; Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S.* Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin. ACS Chem. Biol. 2017, 12, 3093–3102.
19. Xu, X.; Liu, L.; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.* Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici. ChemBioChem 2014, 15, 284–292.
20. Li, E.; Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y.* A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from the Cordyceps-Colonizing fungus Fimetariella sp. Org. Lett. 2012, 14, 3320–3323.
#equal contributions.
