鲁丽
职称/职务：特聘研究员
通讯地址：湖北省武汉市武昌区东湖路185号武汉大学药学院，430071
办公地址：武汉大学医学部1号楼701
学习简历：
2003.09 - 2007.07 华中农业大学，生命科学与技术学院，生物科学理科基地,本科
2006.09 - 2012.12 华中农业大学，生命科学与技术学院，遗传学，博士
工作简历：
2014.04 - 2017.12 美国威斯康星大学麦迪逊分校，遗传学系，博士后
2017.12 - 2018.12 美国威斯康星大学麦迪逊分校，医学研究院，助理研究员
2019.09 至今 武汉大学药学院，特聘研究员
承担课程:
本科生《药用植物学》；《生物信息学》；本科生野外实习实训。
研究领域:
植物天然产物的分子合成途径解析、植物合成生物学、植物来源生物农药、植物香精香料
研究兴趣与方向:
自然界蕴含丰富的植物资源，其天然产物是提供人类药物、营养保健、工业日化的重要来源，也是植物自身与环境互作、吸引昆虫、防御病虫害的主要手段。课题组致力于从植物基因组资源中挖掘活性分子合成基因，利用合成生物学在微生物底盘生产植物来源活性分子。
科研项目:
1. 2023湖北省青年拔尖人才
2. 2023湖北省楚天学子
3. 2022国家重点研发计划“合成生物学”重点专项子课题
4. 2022湖北省自然科学基金青年基金
5. 2021国家自然科学基金青年基金
代表性论文:
1. Xiaosa Chang, Xueting Fang, Yan Yao, Zhenni Xu, Chaoyan Wu,* and Li Lu*. Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin. Journal of Agricultural and Food Chemistry, 2024, doi: 10.1021/acs.jafc.3c09308
2. Yu-Yu Zheng#, Lin-Hua Chen#, Bing-Liang Fan#, Zhenni Xu#, Qiuxia Wang, Bo-Yuan Zhao, Min Gao, Min-Hui Yuan, Muhammad Tahirul Qamar, Yuanyuan Jiang, Liu Yang, Lingqiang Wang, Weihui Li, Wenguo Cai, Chongjian Ma*, Li Lu*, Jia-Ming Song*, Ling-Ling Chen*. Integrative multi-omics profiling of passion fruit reveals the genetic basis for fruit color and aroma. Plant Physiology, 2024, doi:10.1093/plphys/kiad640.
3. Xiaomin Deng#, Ziling Ye#, Jingyu Duan, Fangfang Chen, Yao Zhi, Man Huang, Minjian Huang, Weijia Cheng, Yujie Dou, Zhaolin Kuang, Yanglei Huang, Guangkai Bian, Zixin Deng, Tiangang Liu* and Li Lu*. Complete pathway elucidation and heterologous reconstitution of (+)-nootkatone biosynthesis from Alpinia oxyphylla. New Phytologist. 2024, 241(2):779-792.
4. Weijia Cheng#, Xueting Fang#, Zhifeng Guan#, Yan Yao, Zhenni Xu, Yunya Bi, Kexin Ren, Jiwen Li, Fangfang Chen, Xiangsong Chen, Weihua Ma, Zhaohui Chu, Zixin Deng, Zhengyu Zhang*, Li Lu*. Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defense. Plant Biotechnology Journal. 2023, 21:2611-2624.
5. Weijia Cheng, Yan Yao, Qiuxia Wang, Xiaosa Chang, Zhuolin Shi, Xueting Fang, Fangfang Chen, Shixin Chen, Yonghong Zhang, Fan Zhang, Dongqing Zhu, Zixin Deng, Li Lu*. Characterization of benzylisoquinoline alkaloid methyltransferases in Liriodendron chinense provides insights into the phylogenic basis of angiosperm alkaloid diversity. The Plant Journal. 2022, 112(2):535-548.
6. Kimpara S#, Lu L#, Hoang NM#, Zhu F, Bates PD, Daenthanasanmak A, Zhang S, Yang DT, Kelm A, Liu Y, Li Y, Rosiejka A, Kondapelli A, Bebel S, Chen M, Waldmann TA, Capitini CM, Rui L. EGR1 Addiction in Diffuse Large B-cell Lymphoma. Mol Cancer Res. 2021, 19(8):1258-1269.
7. Li Lu, Fen Zhu, Yangguang Li, Shuichi Kimpara, Nguyet Minh Hoang, Sheida Pourdashti and Lixin Rui*. Inhibition of the STAT3 target SGK1 sensitizes diffuse large B cell lymphoma cells to AKT inhibitors. Blood Cancer journal, 2019, 9 (43).
8. Li Lu#, Xiangsong Chen#, Shuiming Qian, Xuehua Zhong*. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nature communications, 2018, 9 (1), 630.
9. Li Lu#, Fen Zhu#, Meili Zhang#, Yangguang Li, Amanda C. Drennan, Shuichi Kimpara, Ian Rumball, Christopher Selzer, Hunter Cameron, Ashley Kellicut, Amanda Kelm, Fangyu Wang, Thomas A Waldmann*, Lixin Rui*. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. PNAS, 2018, 115 (3), E498-E505.
10. Zeng H#, Lu L#, Chan NT, Horswill M, Ahlquist P, Zhong X*, Xu W*. Systematic identification of Ctr9 regulome in ERα-positive breast cancer. BMC genomics, 2016, 17(1), 902.
11. Li Lu, Xiangsong Chen, Dean Sanders, Shuiming Qian, Xuehua Zhong*. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics, 2015, 10 (11), 1044-1053.
12. Yang Lei#, Li Lu#, Hai-Yang Liu, Sen Li, Feng Xing, Ling-Ling Chen*. CRISPR-P: A web tool for synthetic single-guide RNA design of CRISPR-system in plants. Molecular Plant, 2014, 9:1494-1496.
13. Li Lu, Di Shao, Xianjing Qiu, Liang Sun, Xiangchun Zhou, Wenhao Yan, Lin Yang, Yuqing He, Sibin Yu, Yongzhong Xing*. Natural variation and artificial selection in four genes determine grain shape in rice. New Phytologist, 2013, 200:1269-1280.
14. Li Lu#, Wenhao Yan#, Weiya Xue, Di Shao, Yongzhong Xing*. Evolution and association analysis of Ghd7 in rice. PLoS ONE, 2012, 7: e34021.
15. Hui Li#, Li Lu#, Yanfang Heng, Rui Qin, Yongzhong Xing, Weiwei Jin*. Expression of CENH3 alleles in synthesized allopolyploid Oryza species. Journal of Genetics and Genomics, 2010, 37:703-711.
