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董春娥教授
来源:武汉大学药学院    时间:2011-11-27    编辑:admin    点击:51301

董春娥,2000年毕业于中国科学院成都有机化学研究所有机化学专业获理学博士学位。2000年至2001维也纳大学有机化学研究所博士后2002年至2004加拿大渥太华大学化学系博士后2004年至2006年美国伊利诺伊大学香槟分校化学系博士后

目前主要研究兴趣:

1)  具有潜在药物活性小分子的新法合成研究。

2)  有机化学新方法研究,特别是碳-杂键的构键以及不对称催化研究

3)  生物模拟离子通道的设计合成和活性研究

在研科研项目及经费:

1) 主持国家自然科学基金面上项目(NO: 20972121)2010.1-2012.1230万。

2) 主持武汉大学引进人才科研启动基金(NO: 306276315),2007.12 -2010.1210万。

3) 高等学校博士点新教师基金,2010,1-2012,12, 3.6万。

4) 教育部留学回国基金3

5) 病毒学重点实验室开放基金,20113-2012-123万。

6) 药物中间体的研发,25

代表性文章:

(1) Xin Han, Xiangfei Wu, Chang Min, Hongyu Zhu, Haibing Zhou, Chune Dong*, An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalyst, RSC Advance 2012, 2, 7501-7505.

(2) Zongquan Liao, Xiaoyan Xu, Hai-Bing Zhou, Chune Dong*, A New Pathway for Phthalazine Derivatives via Metal-free Cyclization of ortho-Alkynylphenyl ketones and Hydrazine, J. Heterocycl. Chem., 2013, in press.

(3) Hao Chen, Jianmin Wang, Xuechuan Hong, Haibing Zhou, Chune Dong*, A simple and straightforward approach toward selective C=C bond reduction by hydrazine, Can. J. Chem., 2012, 90, 758-761.

(4) Xin Han, Bin Liu, Hai-Bing Zhou, Chune Dong*, Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel-Crafts reaction of indole with alkyl trifluoro pyruvate, Tetrahedron: Asymmetry, 2012, 23, 1332-1337.

(5) Ze Dong, Guofu Qiu, Hai-Bing Zhou, Chune Dong*, Chiral Squaramide as Multiple H-Bonds Donor Organocatalyst for Asymmetric Michael addition of 1, 3-Dicarbonyl Compounds to Nitroolefins, Tetrahedron: Asymmetry, 2012, 23, 1550-1556.

(6) Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, Haibing Zhou*, Identification and structure-Activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2,2,1]hept-2-ene-7-oxide, J. Med. Chem., 2012, 55 (5), 2324–2341.

(7) Chang Min, Xin Han, Zong quan Liao, Xiangfei Wu, Haibing Zhou, Chune Dong*, C3-symmetric cinchonine-squaramide as new highly efficient and recyclable organocatalyst for enantioselective michael addition, Adv. Syn. Cat. 2011, 353, 2715-2720. Highlighted by ChemInform (2012, 43, 13).

(8) Xiangfei Wu, Chang Min, Enkhtsetseg Nyamzundui, Haibing Zhou, Chune Dong*, A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane, Tetrahedron: Asymmetry, 2011, 22, 1640-1643.

(9) Ze Dong, Xiao qing Jin, Peng cheng Wang, Chang Min, Haibing Zhou, Chune Dong*, Novel bifunctional chiral squaramide-amine catalysts for highly enantioselective addition of mono diketones to nitroalkenes, Arkivoc 2011, (ix), 367-380.

(10) Chune Dong*, Lingli Xie, Xiaohong Mou, Yashan zhong, Wei Su, Facile synthesis of 1,3,4-benzotriazepines and 1-arylamide-1H-indazoles via palladium catalyzed cyclization of aryl isocyanates and aryl hydrazones under microwave irradiation, Org. Biomol. Chem. 2010, 8, 4827-4830. Highlighted by Synfacts (2011, 1, 16).

(11) Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Chune Dong, Jian Huang, HaiBing Zhou, Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo [2.2.1]hepte-ne scaffold and evaluation of their antiproliferative effects, Org. Biomol. Chem. 2012, 10, 9689-9699.

 (12) Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen, Kendall W. Nettles, Haibing Zhou*, Biocyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfon-amides, Org. Biomol. Chem. 2012, 10, 8692-8700.

(13) Yangfan Zheng, Manghong Zhu, Sathish Srinivasam, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn, E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenelle-nbogen, Kendall W. Nettles, Haibing Zhou*, Development of selective estrogen receptor modulator SERM-like activity through an indirect mechanism of estrogen receptor antagonism defining the binding mode of 7-oxabicyclo[2.2.1] hept-5-ene scaffold core ligands, ChemMedChem. 2012, 7, 1094-1100.

 (14) Jian Min, Pengcheng Wang, Chune Dong, Haibing Zhou*, Progress in small molecular inhibitors of protein protein interactions, Chin. J. Org. Chem. 2010, 30, 1778-1789.

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